Wednesday, October 23, 2013

ObamaCare in 2016: Happy Yet?


Three years after the disastrous launch of the Affordable Care Act, most of the website troubles finally have been ironed out. People are now able to log on to the government's ACA website and to most of the state health-insurance exchanges. The public has grudgingly come to accept higher insurance premiums, new taxes and increases in part-time workers who were formerly full-time. But Americans are irate anyway—because now they're seeing the health-care law's destructive effect on the fundamental nature of the way their care is delivered.






Source: http://www.realclearpolitics.com/2013/10/22/obamacare_in_2016_happy_yet_318400.html
Similar Articles: Never Forget 9/11   Tami Erin   Justin Morneau  

Liberal Hand-Wringing Aids the Unhinged Right


As predictably as night follows day, on Monday the media establishment pivoted away from obsessing about GOP extremism and the party’s alleged “civil war” to the “train wreck” that is, allegedly, the Affordable Care Act.



And liberals helped lead the pivot.


Don’t get me wrong: The problems with Healthcare.gov are real, and disturbing, and must be fixed asap. (Think Progress has a dispassionate assessment here.) But excuse me if I believe the president knows that without my telling him. It’s like watching the 21st century version of the rise of the Democratic Leadership Council, and I feel the way I did back then: On the one hand, yes, it’s important for Democrats to acknowledge when government screws up, and to fix it.





Source: http://www.realclearpolitics.com/2013/10/23/liberal_hand-wringing_aids_the_unhinged_right_318407.html
Similar Articles: Cressida Bonas   mariano rivera   monday night football   taylor swift   Laurie Forman  

5 Million Lines of Obfuscation

Last weekend, some anonymous “specialist” told the New York Times that “5 million lines of software code may need to be rewritten” in order to fix the mess that is healthcare.gov. (The good news, according to the source, is that the project has a total of “500 million lines of software code,” so only 1 percent has to be rewritten. So the code’s 99 percent good—or something.)














I don’t mean to jump back on my hobbyhorse of complaining about lack of knowledge in tech journalism, but printing a claim like that is egregious.










Why? Well, here’s a line of C++ code:
















The close curly brace signals the end of a block of code. It could be put on the same line as the previous, more substantive line, but for the sake of cleanliness, programmers tend to put it on a line of its own. When it comes to coding in HTML, Perl, and AJAX, different programmers have different styles. Some will split code up into many lines; others will compress it into a handful of lines. I’ve seen nearly identical segments of code written in 10 lines or in 50.










Here’s another line of C++ code.










// TODO: make sure this code doesn’t crash!










That’s a comment. It doesn’t do anything—those two slashes at the beginning tell the compiler (which converts code into actual computer instruction) to ignore the line. It’s there to explain things to people reading the source code, or in this case to remind the programmer to fix whatever lies immediately below. I’ve written cryptic bits of code that required more lines of comments than lines of actual code, simply to explain what on earth was going on.










On the other hand, here’s a line of APL (“A Programming Language”) code:










(~R∊R∘.×R)/R←1↓ιR










That code prints out all the prime numbers from 1 to R. APL is a notoriously terse and nightmarish language. I have successfully avoided ever coding in it. One single line of APL code could contain half a dozen bugs.










The sources may well be “specialists,” but their specialty is more likely the art of procuring government contracts.










So not all lines of code are created equal. As a programmer, I had weeks where I produced 1,000 lines of code. I had weeks where I produced 20. Usually the latter weeks were more grueling, because any 20 lines requiring that much time and effort are going to be a) important, b) complicated, and c) bug-prone. The 1,000 lines were far more likely to be simple stuff that I could code by rote. I even had weeks where I removed 2,000 lines of code by removing redundancies between similar blocks of code. Those were the best weeks of all, because less code means fewer bugs.










Programmers who do user interface code—which is responsible for the visuals and input components of software—tend to produce far more code than other programmers, because user interface code requires a lot of boilerplate. I knew programmers who wrote 10,000 (good) lines of user interface code in a week. Many of them were copied and slightly modified from other projects or example code.










Consequently, it’s rather silly to say, as the Times article does, that “a large bank’s computer system is typically” 100 million lines of code. Investment banks have far more complex code than commercial banks—they need more in order to do all their clever, sneaky trading. Assuming the Times is referring to commercial banks, there is such variety among implementations and coding standards that speaking of an “average” amount of code is meaningless. Bank code written in FORTRAN will be far longer than bank code written in Python. Does it make a difference? Not really.










But while the numbers in the Times article don’t tell us much about the healthcare.gov codebase itself, they do tell us something about the “specialist” sources that inform the article. The sources are not programmers, because programmers would not speak in terms of lines of code with no further context. We hear that “disarray has distinguished the project” in part because government “officials modified hardware and software requirements for the exchange seven times.” The officials probably modified them 70 times—requirements for any software project are constantly in flux, and it’s expected that project managers and software engineers will adapt. Modifications alone do not signal a project in disarray.










We hear that the Centers for Medicare and Medicaid Services (CMS) lacked the expertise to link the individual pieces of healthcare.gov together. That does not explain why the “data hub”—the single component provided by Quality Software Services Inc.—proved to be “a particular source of trouble,” something I had surmised two weeks ago. If individual contractors were producing garbage, CMS’s expertise or lack thereof wouldn’t have made a difference to the final product.










The sources also say that CGI Federal, which won the $90 million contract to develop healthcare.gov’s back end, was asked to replace the data hub, though this approach was abandoned as “too risky.” That’s a hint that the article’s sources seem eager to shift the blame to CMS, to the White House, and to QSSI, and away from CGI. The Times claims that CGI was not responsible for healthcare.gov’s “integration,” but the Washington Post’s Lydia DePillis reports that CGI Federal was in fact responsible for “knitting all the pieces together, making Quality Software Services’ data hub work seamlessly with Development Seed’s sleek user interface and Oracle’s identity management software.”










I have no idea who the Times’ sources were, but they sure sound like employees of CGI Federal. Because they almost certainly aren’t programmers, I’d guess they are probably mid- or high-level managers who are trying to salvage CGI Federal’s reputation. They may well be “specialists,” but their specialty is more likely the art of procuring government contracts.










This is to be expected. What’s less expected is that such anonymous sources would be treated with this degree of credulity by national reporters who lack technical understanding of their subject matter and are thus more likely to parrot whatever a “specialist” tells them. The Times has a great tech reporter, Natasha Singer, who has done well-informed work on consumer profiling, taking little for granted. They should put her on this story.








Source: http://www.slate.com/articles/technology/bitwise/2013/10/healthcare_gov_problems_what_5_million_lines_of_code_really_means.html
Tags: Americas Cup   miss america   Breaking Bad Season 5 Episode 11   Eydie Gorme   cote de pablo  

The Fix: How Jon Stewart became President Obama’s biggest problem (Washington Post)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.
Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/335729550?client_source=feed&format=rss
Similar Articles: steve bartman   Colorado flooding   freedom tower   school shooting   whitney houston  

Tuesday, October 22, 2013

Reds choose Bryan Price for next manager

FILE - In this May 26, 2012, file photo, Cincinnati Reds pitching coach Bryan Price watches a baseball game against the Colorado Rockies, in Cincinnati. The Reds have chosen Price to replace Dusty Baker as their next manager, according to a person familiar with the decision. The club plans to introduce the 51-year-old Price at a news conference later Tuesday, Oct. 22, 2013. The person spoke on condition of anonymity because no announcement had been made.(AP Photo/David Kohl, File)







FILE - In this May 26, 2012, file photo, Cincinnati Reds pitching coach Bryan Price watches a baseball game against the Colorado Rockies, in Cincinnati. The Reds have chosen Price to replace Dusty Baker as their next manager, according to a person familiar with the decision. The club plans to introduce the 51-year-old Price at a news conference later Tuesday, Oct. 22, 2013. The person spoke on condition of anonymity because no announcement had been made.(AP Photo/David Kohl, File)







Cincinnati Reds starting pitcher Bronson Arroyo (61) talks with pitching coach Bryan Price during the third inning of a baseball game against the Pittsburgh Pirates, Saturday, Sept. 28, 2013, in Cincinnati. (AP Photo/Al Behrman)







FILE - This is a Feb. 16, 2013, file photo showing Cincinnati Reds pitching coach Bryan Price. The Reds have chosen Price to replace Dusty Baker as their next manager, according to a person familiar with the decision. The club plans to introduce the 51-year-old Price at a news conference later Tuesday, Oct. 22, 2013. The person spoke on condition of anonymity because no announcement had been made. (AP Photo/Paul Sancya, File)







(AP) — The Reds stayed in-house for their next manager, giving pitching coach Bryan Price a three-year deal Tuesday to take the team deep into the playoffs.

The job carries enormous expectations for the 51-year-old Price, who has been one of the most successful pitching coaches in the majors but has never managed at any level. He and Triple-A manager Jim Riggleman were two in-house candidates considered for the job.

Dusty Baker led the Reds to three 90-win seasons and three playoff appearances in the last four years, but Cincinnati got knocked out in the first round of the postseason each time.

The Reds fired Baker with a year left on his two-year contract after a final-week fade that included an implosion by the pitching staff. Cincinnati lost its last six games, including a 6-2 defeat at PNC Park in the wild-card playoff against the Pirates. General manager Walt Jocketty said the closing slump was a major factor in the decision to change managers.

Baker led the Reds to their best stretch of success since Sparky Anderson managed the Big Red Machine to World Series titles in the 1970s. Price will be expected to keep Cincinnati winning deep into the playoffs in 2014 with the core of the team under contract.

Like Baker, he has an even-keel personality. Unlike Baker, he comes to the job with no previous managing experience.

"We've all seen his work here with our pitching staff," Jocketty said in a statement. "He has proven himself to be an excellent communicator and leader and clearly is one of the most respected people not only in our clubhouse but in baseball in general."

Price was a left-handed pitcher for six years in the minors, his career scuttled by elbow surgery. He started his coaching career in Seattle's farm system and was the Mariners' pitching coach from 2000-05. He moved to Arizona as pitching coach from 2006-09, resigning there after Bob Melvin was replaced.

Jocketty hired him to replace Dick Pole in Cincinnati, where he helped the Reds' staff develop into one of the NL's best during his four seasons working with Baker. Now, Jocketty has several important lineup decisions to make to try to keep the Reds competitive in the NL Central, which sent three teams to the playoffs.

Division champion St. Louis opens the World Series against Boston on Wednesday. The Pirates passed up the Reds for second place and home-field advantage for the wild-card playoff during the final week of the season.

The pitching staff will have some changes in the offseason, with starter Bronson Arroyo eligible for free agency after completing his contract. Left-hander Tony Cingrani made his debut last season and showed he could win in the majors, but was sidelined by back problems in September. Ace Johnny Cueto missed most of the season with shoulder problems.

The Reds have to decide whether to keep left-hander Aroldis Chapman as their closer or move him into a starting role.

The offense struggled last season with no consistent right-handed hitter. Cleanup hitter Ryan Ludwick tore cartilage in his right shoulder on a slide on opening day and missed most of the season. He hit only two homers after his return in mid-August, with the shoulder still bothering him. Brandon Phillips drove in 100 runs for the first time in his career, but no other right-handed hitter produced runs with any consistency.

Joey Votto and leadoff hitter Shin-Soo Choo led the NL in on-base percentage, but Choo is a free agent. Billy Hamilton created a sensation with his speed when he was called up in September, but struggled to get on base consistently in Triple-A before his first promotion to the majors.

___

Follow Joe Kay on Twitter: http://twitter.com/apjoekay

Associated PressSource: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-10-22-Reds%20Manager/id-6c76b29496c9462f9ca96bdb9a4b4c7c
Similar Articles: columbus day   reggie bush   friday the 13th   heidi klum   Royal Baby Pictures  

Teacher Who Died Trying To End Shooting Remembered As A Hero





A Sparks Middle School student cries with family members after a fellow student killed a math teacher and himself Monday in Sparks, Nev.



Kevin Clifford/AP


A Sparks Middle School student cries with family members after a fellow student killed a math teacher and himself Monday in Sparks, Nev.


Kevin Clifford/AP


Michael Landsberry, the 45-year-old middle school math teacher and Afghan War veteran who was killed Monday trying to talk down a student shooter at a Nevada middle school, is being remembered as a hero.


Witnesses at Sparks Middle School in the city of Sparks, near Reno, described how Landsberry approached the armed 13-year-old boy and tried to get him to surrender a semi-automatic pistol he had used to shoot two fellow students. The boy then turned the weapon on Landsberry, fatally shooting him, before using the pistol to take his own life.


"In my estimation he is a hero," Reno Deputy Police Chief Tom Robinson said at a news conference Monday.


Washoe County School District Superintendent Pedro Martinez said: "We have a lot of heroes today, including our children ... and our fallen hero, an amazing teacher."


A Facebook page in honor of the fallen teacher "Rest Easy Mr. Landsberry" had more than 12,000 "likes." Other photos of Landsberry can be seen here.


"It's very unfortunate that [the life of] someone like that, who protected our country over there and came back alive ... had to be taken at his work, at a school," Sparks Mayor Geno Martini said, according to CNN.


Landsberry, a former U.S. Marine who later served in Afghanistan with the Nevada Air National Guard and held the rank of senior master sergeant, wrote on his classroom webpage: "One of my goals is to earn your respect while you earn mine. I believe that with mutual respect that the classroom environment will run smoothly."


Chanda Landsberry said her brother-in-law loved teaching.


"He loved his schoolkids. He loved the Guard," she said. "It defined him."


She said he leaves behind his wife, Sharon, and two stepdaughters.


Authorities tell ABCNews that one of the wounded boys had been through surgery and the second is said to be "doing well."


Source: http://www.npr.org/blogs/thetwo-way/2013/10/22/239681615/teacher-who-died-trying-to-end-shooting-remembered-as-a-hero?ft=1&f=1013
Category: tim tebow   silk road   Teyana Taylor   Blacklist   cnet  

WSJ: Microsoft prototyping Google Glass-like device

It's pretty clear that wearables, whether they be made for the face or the wrist, are going to be the next big thing in hardware. According to The Wall Street Journal's sources "familiar with the matter," Microsoft doesn't want to be late to the party, and is currently playing with prototypes of ...


Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/iBnpRKhLh7s/
Category: Ed Lauter   cory booker   National Cheeseburger Day   Sons Of Anarchy Season 6   Eddie Lacy  

Kanye West and Kim Kardashian Are Engaged (Report)



Rapper Kanye West and reality TV star Kim Kardashian are engaged, E! News reports.



The two pop culture icons, who are parents to 4-month-old daughter North, have been dating since early 2012. According to E!, the network that airs the highly successful Keeping Up With the Kardashians series, West proposed in front of their friends and family at AT&T Park in San Francisco on Monday night, which also happened to be Kardashian's birthday.


PHOTOS: The Kardashian Family's Summer of Bummers


The hip-hop star is in the Bay Area for his current Yeezus Tour, which is scheduled to stop in San Jose, Calif. on Tuesday night. The trek kicked off this past weekend and has already made headlines for its theatrical visuals -- which include a Jesus who shares the stage with West -- and a wardrobe malfunction


Hours before popping the question to his longtime crush, West was a presenter at the Hollywood Film Awards.


The Hollywood Reporter has reached out to reps for West and Kardashian for confirmation.


Twitter: @THR_Earshot



Source: http://feedproxy.google.com/~r/thr/television/~3/coWg-FxJH_M/story01.htm
Related Topics: walking dead   Tony Gonzalez   Miss World 2013   bob newhart   Andre Drummond  

Builders of Obama's health website saw red flags

President Barack Obama gestures while speaking in the Rose Garden of the White House in Washington, Monday, Oct. 21, 2013, on the initial rollout of the health care overhaul. Obama acknowledged that the widespread problems with his health care law's rollout are unacceptable, as the administration scrambles to fix the cascade of computer issues. (AP Photo/Charles Dharapak)







President Barack Obama gestures while speaking in the Rose Garden of the White House in Washington, Monday, Oct. 21, 2013, on the initial rollout of the health care overhaul. Obama acknowledged that the widespread problems with his health care law's rollout are unacceptable, as the administration scrambles to fix the cascade of computer issues. (AP Photo/Charles Dharapak)







President Barack Obama, standing with supporters of his health care law, speaks in the Rose Garden of the White House in Washington, Monday, Oct. 21, 2013, on the initial rollout of the health care overhaul. Obama acknowledged that the widespread problems with his health care law's rollout are unacceptable, as the administration scrambles to fix the cascade of computer issues. (AP Photo/Charles Dharapak)







President Barack Obama gestures while speaking in the Rose Garden of the White House in Washington, Monday, Oct. 21, 2013, on the initial rollout of the health care overhaul. Obama acknowledged that the widespread problems with his health care law's rollout are unacceptable, as the administration scrambles to fix the cascade of computer issues. (AP Photo/ Evan Vucci)







WASHINGTON (AP) — Crammed into conference rooms with pizza for dinner, some programmers building the Obama administration's showcase health insurance website were growing increasingly stressed. Some worked past 10 p.m., energy drinks in hand. Others rewrote computer code over and over to meet what they considered last-minute requests for changes from the government or other contractors.

As questions mount over the website's failure, insider interviews and a review of technical specifications by The Associated Press found a mind-numbingly complex system put together by harried programmers who pushed out a final product that congressional investigators said was tested by the government and not private developers with more expertise.

Project developers who spoke to the AP on condition of anonymity — because they feared they would otherwise be fired — said they raised doubts among themselves whether the website could be ready in time. They complained openly to each other about what they considered tight and unrealistic deadlines. One was nearly brought to tears over the stress of finishing on time, one developer said. Website builders saw red flags for months.

A review of internal architectural diagrams obtained by the AP revealed the system's complexity. Insurance applicants have a host of personal information verified, including income and immigration status. The system connects to other federal computer networks, including ones at the Social Security Administration, IRS, Veterans Administration, Office of Personnel Management and the Peace Corps.

President Barack Obama on Monday acknowledged technical problems that he described as "kinks in the system." He also promised a "tech surge" by leading technology talent to repair the painfully slow and often unresponsive website that has frustrated Americans trying to enroll online for insurance plans at the center of Obama's health care law.

But in remarks at a Rose Garden event, Obama offered no explanation for the failure except to note that high traffic to the website caused some of the slowdowns. He said it had been visited nearly 20 million times — fewer monthly visits so far than many commercial websites, such as PayPal, AOL, Wikipedia or Pinterest.

"The problem has been that the website that's supposed to make it easy to apply for and purchase the insurance is not working the way it should for everybody," Obama said. "There's no sugarcoating it. The website has been too slow. People have been getting stuck during the application process. And I think it's fair to say that nobody is more frustrated by that than I am."

The online system was envisioned as a simple way for people without health insurance to comparison-shop among competing plans offered in their state, pick their preferred level of coverage and cost and sign up. For many, it's not worked out that way so far.

Just weeks before the launch of HealthCare.gov on Oct. 1, one programmer said, colleagues huddled in conference rooms trying to patch "bugs," or deficiencies in computer code. Unresolved problems led to visitors experiencing cryptic error messages or enduring long waits trying to sign up.

Congressional investigators have concluded that the government's Centers for Medicare and Medicaid Services, not private software developers, tested the exchange's computer systems during the final weeks. That task, known as integration testing, is usually handled by software companies because it ferrets out problems before the public sees the final product.

The government spent at least $394 million in contracts to build the federal health care exchange and the data hub. Those contracts included major awards to Virginia-based CGI Federal Inc., Maryland-based Quality Software Services Inc. and Booz Allen Hamilton Inc.

CGI Federal said in a statement Monday it was working with the government and other contractors "around the clock" to improve the system, which it called "complex, ambitious and unprecedented."

The schematics from late 2012 show how officials designated a "data services hub" — a traffic cop for managing information — in lieu of a design that would have allowed state exchanges to connect directly to government servers when verifying an applicant's information. On Sunday, the Health and Human Services Department said the data hub was working but not meeting public expectations: "We are committed to doing better."

Administration officials so far have refused to say how many people actually have managed to enroll in insurance during the three weeks since the new marketplaces became available. Without enrollment numbers, it's impossible to know whether the program is on track to reach projections from the Congressional Budget Office that 7 million people would gain coverage during the first year the exchanges were available.

Instead, officials have selectively cited figures that put the insurance exchanges in a positive light. They say more than 19 million people have logged on to the federal website and nearly 500,000 have filled out applications for insurance through both the federal and state-run sites.

The flood of computer problems since the website went online has been deeply embarrassing for the White House. The snags have called into question whether the administration is capable of implementing the complex policy and why senior administration officials — including the president — appear to have been unaware of the scope of the problems when the exchange sites opened.

Even as the president spoke at the Rose Garden, more problems were coming to light. The administration acknowledged that a planned upgrade to the website had been postponed indefinitely and that online Spanish-language signups would remain unavailable, despite a promise to Hispanic groups that the capability would start this week. And the government tweaked the website's home page so visitors can now view phone numbers to apply the old-fashioned way or window-shop for insurance rates without registering first.

The House Energy and Commerce Committee was expected to conduct an oversight hearing Thursday, probably without Health and Human Services Secretary Kathleen Sebelius testifying. She could testify on Capitol Hill on the subject as early as next week.

Uninsured Americans have until about mid-February to sign up for coverage if they are to meet the law's requirement that they be insured by the end of March. If they don't, they will face a penalty.

On Monday, the White House advised people frustrated by the online tangle that they can enroll by calling 1-800-318-2596 in a process that should take 25 minutes for an individual or 45 minutes for a family. Assistance is also available in communities from helpers who can be found at LocalHelp.HealthCare.gov.

___

Associated Press writer Ricardo Alonso-Zaldivar contributed to this report.

___

Follow Jack Gillum on Twitter at http://twitter.com/jackgillum or Julie Pace at http://twitter.com/jpaceDC.

Associated PressSource: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-10-22-US-Obama-Health-Care/id-128f42ddd5df44f1a43d489002ad722c
Tags: Ed Sheeran   AirDrop   National Cheeseburger Day   catherine zeta jones   usain bolt  

Kristen Bell Flashes Her Wedding Ring While Running Errands After Simple Marriage Ceremony to Dax Shepard


Nothing to hide here! After keeping her simple courthouse wedding ceremony to now-hubby Dax Shepard very quiet, actress Kristen Bell stepped out on Sunday, Oct. 20 flashing her new wedding band. 


The House of Lies star, 32, wed her fiancé of almost three years in a "no-frills" ceremony on Oct. 16. 


PHOTOS: Kristen Bell and Dax Shepard's fun-filled romance


Bell confirmed her marriage on Twitter on Oct. 18 saying, "Wife coffee tastes way better than regular coffee in the morning :) @daxshepard1." 


Though the couple got engaged in late 2009, they decided to hold off on getting married until same-sex marriage bans were overturned nationwide. 


PHOTOS: Kristen Bell's pregnancy style


In June 2013 Bell re-proposed to Shepard after the U.S. Supreme Court overturned the Defense of Marriage Act and Proposition 8 was overturned in California. 


The couple welcomed daughter Lincoln in March 2013. 


PHOTOS: Costar couples


Bell currently stars in the Showtime series House of Lies as Jeannie Van Der Hooven and recently finished filming the highly-anticipated, Kickstarter-funded Veronica Mars movie in the title role. 


Shepard continues to play Crosby Braverman in season 5 of Parenthood and will also appear in the Veronica Mars movie. 


Source: http://www.usmagazine.com/celebrity-news/news/kristen-bell-flashes-her-wedding-ring-running-errands-marriage-ceremony-dax-shepard--20132110
Similar Articles: reggie wayne   christina milian   britney spears   vince young   food network star  

Ludwig scientist Richard D. Kolodner elected to the Institute of Medicine

Ludwig scientist Richard D. Kolodner elected to the Institute of Medicine


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

21-Oct-2013



[


| E-mail

]


Share Share

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research





October 21, 2013, New York, NY Ludwig scientist Richard D. Kolodner, PhD, has been elected as one of 70 new members to the Institute of Medicine (IOM) today. Election to the IOM is one of the highest honors in the fields of health and medicine.


Established in 1970 by the National Academy of Sciences, the IOM serves as an advisory organization to Congress and policy makers on important health questions. During the past year, projects included health IT and patient safety, treatment of post-traumatic stress disorder, nutrition rating systems and food packaging graphics, and studies of environmental factors in breast cancer.


Kolodner's research has played a seminal role in the understanding of cancer genetics, and he pioneered many techniques that have become standard tools in genetics research. His fundamental discoveries in the field of DNA mismatch repair, the ability of cells to repair genetic errors that could disrupt the integrity of DNA, and its connection to human cancer, led to his being elected to the National Academy of Sciences in 2000 and the American Academy of Arts & Sciences in 2008.


He has served on numerous advisory and review boards, including the Board of Scientific Counselors of the National Cancer Institute, the Howard Hughes Medical Institute Scientific Review Board, the Scientific Review Council of the Cancer Prevention & Research Institute of Texas and the Scientific Advisory Committee of the AACR-Stand Up to Cancer Foundation. Kolodner received his PhD in biological sciences from UC Irvine. Following his post-doctoral work at Harvard, he was a professor at Harvard Medical School Department of Biological Chemistry and Molecular Pharmacology and the Dana-Farber Cancer Institute Department of Cancer Biology until joining the Ludwig Institute for Cancer Research in 1997.


###


Kolodner is a member of the Ludwig Institute for Cancer Research and is based at the University of California, San Diego School of Medicine.


About Ludwig Cancer Research

Ludwig Cancer Research is an international collaborative network of acclaimed scientists with a 40-year legacy of pioneering cancer discoveries. Ludwig combines basic research with the ability to translate its discoveries and conduct clinical trials to accelerate the development of new cancer diagnostics and therapies. Since 1971, Ludwig has invested more than $1.6 billion in life-changing cancer research through the not-for-profit Ludwig Institute for Cancer Research and the six U.S.-based Ludwig Centers. http://www.ludwigcancerresearch.org


For further information please contact Rachel Steinhardt, rsteinhardt@licr.org or +1-212-450-1582.




[ Back to EurekAlert! ]

[


| E-mail


Share Share

]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Ludwig scientist Richard D. Kolodner elected to the Institute of Medicine


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

21-Oct-2013



[


| E-mail

]


Share Share

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research





October 21, 2013, New York, NY Ludwig scientist Richard D. Kolodner, PhD, has been elected as one of 70 new members to the Institute of Medicine (IOM) today. Election to the IOM is one of the highest honors in the fields of health and medicine.


Established in 1970 by the National Academy of Sciences, the IOM serves as an advisory organization to Congress and policy makers on important health questions. During the past year, projects included health IT and patient safety, treatment of post-traumatic stress disorder, nutrition rating systems and food packaging graphics, and studies of environmental factors in breast cancer.


Kolodner's research has played a seminal role in the understanding of cancer genetics, and he pioneered many techniques that have become standard tools in genetics research. His fundamental discoveries in the field of DNA mismatch repair, the ability of cells to repair genetic errors that could disrupt the integrity of DNA, and its connection to human cancer, led to his being elected to the National Academy of Sciences in 2000 and the American Academy of Arts & Sciences in 2008.


He has served on numerous advisory and review boards, including the Board of Scientific Counselors of the National Cancer Institute, the Howard Hughes Medical Institute Scientific Review Board, the Scientific Review Council of the Cancer Prevention & Research Institute of Texas and the Scientific Advisory Committee of the AACR-Stand Up to Cancer Foundation. Kolodner received his PhD in biological sciences from UC Irvine. Following his post-doctoral work at Harvard, he was a professor at Harvard Medical School Department of Biological Chemistry and Molecular Pharmacology and the Dana-Farber Cancer Institute Department of Cancer Biology until joining the Ludwig Institute for Cancer Research in 1997.


###


Kolodner is a member of the Ludwig Institute for Cancer Research and is based at the University of California, San Diego School of Medicine.


About Ludwig Cancer Research

Ludwig Cancer Research is an international collaborative network of acclaimed scientists with a 40-year legacy of pioneering cancer discoveries. Ludwig combines basic research with the ability to translate its discoveries and conduct clinical trials to accelerate the development of new cancer diagnostics and therapies. Since 1971, Ludwig has invested more than $1.6 billion in life-changing cancer research through the not-for-profit Ludwig Institute for Cancer Research and the six U.S.-based Ludwig Centers. http://www.ludwigcancerresearch.org


For further information please contact Rachel Steinhardt, rsteinhardt@licr.org or +1-212-450-1582.




[ Back to EurekAlert! ]

[


| E-mail


Share Share

]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-10/lifc-lsr102113.php
Tags: sons of anarchy   catherine zeta jones   elvis presley   Shawn Burr   Brickyard 400  

Chael Sonnen and Wanderlei Silva to coach The Ultimate Fighter Brazil 3


Chael Sonnen and Wanderlei Silva are taking their rivalry to primetime. The two light heavyweights have been selected to coach the upcoming season of The Ultimate Fighter Brazil.


UFC President Dana White announced the news to Sonnen firsthand during a brief interview on FOX Sports Live.


Wandy's latest video


"You two will coach The Ultimate Fighter. You will have a ton of security down there with you, and it should be a fun season," a smiling White told Sonnen.


Sonnen (29-13-1) and Silva (35-12-1, 1 NC) are set to begin filming before the end of the year, likely following Sonnen's battle against Rashad Evans at UFC 167.


Both Sonnen and Silva have coached The Ultimate Fighter once in the past. Sonnen squared off against Jon Jones on TUF 17, while Silva dueled Vitor Belfort on the inaugural season of TUF Brazil.


Following TUF Brazil 3's airing, the two rivals will collide inside the Octagon, finally putting an end to their lengthy war of words.



Source: http://www.mmafighting.com/2013/10/21/4864922/chael-sonnen-and-wanderlei-silva-to-coach-the-ultimate-fighter-brazil
Similar Articles: Talk Like a Pirate Day   Breaking Bad Season 5 Episode 10   Lisa Robin Kelly   Dufnering   Edward Snowden  

Monday, October 21, 2013

Android Central Live coming to Samsung Developers Conference next week

iMore's sibling site, Android Central will be doing Android Central Live at next week's Samsung Developer Conference. That's right, Samsung is holding their own dev event, and AC is their official community partner. What can you expect from their amped up coverage? Pretty much what Mobile Nations did for BlackBerry with CrackBerry Live last spring. That means live interviews, show coverage, podcasts, and more, all hosted by our very own Phil Nickinson and Andrew Martonik.

So if you're into Android, Android Central, Samsung, or simply want to meet some great people from Mobile Nations, and you're in San Francisco, grab a ticket and head on over. Otherwise, keep your browsers locked to http://androidcentral.com/sdc13 for all the action.

Any questions? Check out the MarketWired press release below!

Android Central is the Official Community Partner of the Samsung Developers Conference

AndroidCentral.com to provide live coverage, interviews and demos from the floor of Samsung’s debut developer event

SAN FRANCISCO, CA - (Marketwire – October 21, 2013) - Mobile Nations today announced that Android Central, the premier online destination for Android smartphone and tablet owners, will be the Official Community Partner of the upcoming Samsung Developers Conference. The event takes place at San Francisco’s St. Francis Hotel, from October 28-29, 2013. Android Central will be providing live coverage, interviews and demos with Samsung engineers as well as Android app developers from the show floor.

The inaugural Samsung Developers Conference will feature more than 50 technical sessions, hands-on workshops and inspiring talks from leading influencers in the mobile, consumer electronics and digital content industries.

Hosted by Phil Nickinson and Andrew Martonik, Android Central Live will air on October 28th and 29th. Each day will feature the Android Central show, a 1-hour discussion wrapping up and analyzing all the day’s news, and 2 hours of interviews with developers, session leaders and other notables.

“Samsung is the dominant player in Android-based mobile devices today, and its ecosystem stretches beyond phones and tablets,” said Phil Nickinson, Editor in Chief of Android Central. “It’s great to see Samsung take this leap to hosting its own Dev Con. We’re happy to be the official community partner and help bring the event to the entire world. If you can’t be there in person, the absolute best way to share in the excitement is Android Central Live.”

For more information on show times, guests and to watch the live stream and join in the conversation, go to androidcentral.com/sdc13.

Tickets to the Samsung Developer Conference cost $299 and include access to keynotes, sessions, and more. Additional information about the conference, including details on how to register, can be found at www.samsungdevcon.com.


    






Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/N-OLXOWVyDo/story01.htm
Similar Articles: charlie hunnam   miami dolphins   george strait   teresa giudice   food network star  

How Crazy Are the Democrats? (Powerlineblog)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.
Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/335307537?client_source=feed&format=rss
Related Topics: james franco   gucci mane   Jack Nicholson   lsu football   H&m  

After Problem-Plagued Year, Microsoft Re-Surfaces

After Problem-Plagued Year, Microsoft Re-Surfaces
We liked the Surface devices Microsoft released last year, and these even better. But they aren't without problems, some of which are significant.


Source: http://feedproxy.google.com/~r/GearFactor/~3/utapgxHX8Y4/
Similar Articles: calvin johnson   Henry Blackaby  

Ranchers Wonder If U.S. Sheep Industry Has Bottomed Out





Ranches like Double J Feeders in Ault, Colo., are feeling the industry contraction, whether it's caused by epic drought, scarce feed supplies, harsh winters or wild price volatility.



Luke Runyon/Harvest Public Media/KUNC


Ranches like Double J Feeders in Ault, Colo., are feeling the industry contraction, whether it's caused by epic drought, scarce feed supplies, harsh winters or wild price volatility.


Luke Runyon/Harvest Public Media/KUNC


Over the last 20 years, the number of sheep in this country has plummeted by one half. The sheep industry has actually been declining since the late 1940s, when it hit its peak.


The sharp drop in production has left ranchers to wonder, "When are we going to hit the bottom?"


Some sheep are raised for their wool, others primarily for food. Both products – lamb meat and wool – have seen declining consumption in the U.S.


If you look at the tags on clothes in your closet, chances are quite a few pieces will be blended with synthetic fibers: nylon, rayon and polyester. As these human-made fibers have become more prevalent and inexpensive, people are wearing less and less wool.


The same goes for lamb. In the early 1960s, the average person in the U.S. ate about 4.5 pounds of lamb in a year. That has dropped to less than a pound in 2011.


At the same time as the American sheep industry's decline, Australian and New Zealand wool and lamb imports are way up, squeezing into niche markets that America's sheep producers are having a hard time filling.


Ranchers are feeling the industry contraction, whether it's caused by epic drought, scarce feed supplies, harsh winters or wild price volatility.





Congress ending subsidies, wolves, frost, droughts and other hazards have all played a role in the decline in demand for sheep. But farmers markets and demand for locally-sourced food is helping sheep farmers find a niche.



Luke Runtyon/Harvest Public Media/KUNC


Congress ending subsidies, wolves, frost, droughts and other hazards have all played a role in the decline in demand for sheep. But farmers markets and demand for locally-sourced food is helping sheep farmers find a niche.


Luke Runtyon/Harvest Public Media/KUNC


"The numbers are just way down – and less sheep ranchers, just in general," says Albert Villard, a sheep rancher in Craig, Colo.


Blizzard and drought the past three years have culled Villard's herd to its lowest point in a long time. Building it back up hasn't been easy.


"The industry as a whole, I think, is trying to get the numbers up, but there's so many factors as to why," Villard says. "I don't think you can blame any one thing."


Double J Feeders outside Ault, Colo., which is one of just a handful of lamb feeding operations in the country, feels the decline too. The feedlot can hold up to 50,000 sheep at any given time and fattens them up before slaughter.


One part of the decline could be the changing agricultural landscape across the country. Farms have grown larger and more technologically advanced, and there are fewer small family farms today than ever before.


"Thirty or 40 years ago, every farmer in the winter time would buy 1,000 lambs, run them out on the beet tops, corn – whatever – and then they'd market those lambs in the spring. Well, all that has changed," says Jeff Hasbrouck, the owner of Double J Feeders.


Most farms aren't fenced in any more, Hasbrouck says, and have grown so large that maintaining a sheep herd makes no economic sense. It's more trouble than it's worth for a large crop grower.


Another problem that has plagued the industry is lamb's perception by the average consumer. Longtime sheep producers put the blame on the meat fed to soldiers all the way back in World War II.


"Those troops were fed canned mutton and when they came home they said, 'No more lamb, no more sheep. Don't eat any of it.' And that's where we saw the steady decline," says Brad Anderson, livestock supply manager for Mountain States Rosen, a large co-op that markets lamb to meatpacking companies and locks in prices.


Sheep numbers tanked even faster 20 years ago when Congress ended subsidies for sheep ranchers with the repeal of the National Wool Act in 1993. The removal of those subsidies sent the sheep industry into wild market swings and stayed volatile for years. The increased risk, Anderson says, pushed many ranchers out of business.


Today, ranchers who are left face new problems like wolf attacks. Peter Orwick, director of the American Sheep Industry Association, says an attack this year in Idaho left more than a hundred sheep dead.


"In spite of having herders out there, the wolves still come right in, the horses scream, the dogs lay down and whine and they ran sheep over a cliff," Orwick says.



But there is hope for sheep producers. Because many sheep and lamb operations tend to be small, the growth in farmers markets and local food has benefited sheep ranchers. One-third of all lamb sold in the U.S. now is direct sale from producer to consumer, according to the American Sheep Industry Association. There's plenty of room for growth in big cities, too.



"It's ethnic communities. Every major metropolitan city in the U.S. has a large immigrant neighborhood," Orwick says. "Where are the people coming from? Where they prefer lamb. It's their meat."


As the face of America changes, ranchers will be watching those new markets to see whether or not they grow fast enough to keep their industry from shrinking even further.


Luke Runyon reports from Colorado for KUNC and Harvest Public Media, a public radio reporting collaboration that focuses on agriculture and food production issues. A version of this story originally appeared on Harvest Public Media's site.


Source: http://www.npr.org/blogs/thesalt/2013/10/21/238899518/ranchers-worry-as-demand-for-sheep-declines?ft=1&f=3
Tags: Bum Phillips   BART strike   LC Greenwood   will smith   Lauren Silverman  

Federal Employees Return To Work


Yesterday Congress brought the country back from the brink of defaulting on its debt. Host Michel Martin talks to Joe Davidson of The Washington Post about how federal workers will bring the government back to life.



Copyright © 2013 NPR. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.


MICHEL MARTIN, HOST:


And now we'd like to check back in with Joe Davidson who writes the column the Federal Diary for the Washington Post. We've been hearing from him about the government shutdown, the effect that it's had on the hundreds of thousands of federal employees both in the Washington, D.C. area and around the country. And he's back with us now from the studios at the Post. Welcome back, Joe. Thanks so much for joining us.


JOE DAVIDSON: Thank you for having me, Michel.


MARTIN: So Congress reached the deal. The president signed the deal. The government is open, but does that mean that things are really back online? Are most of the furloughed employees back at work today?


DAVIDSON: Well, I think they are at least starting to come back. The announcement was made early in the wee hours of the morning, but I'm pretty sure that most federal employees were paying attention to the news and realized what was going on and that the agreement was in the process of being reached. So I do think that most are back today, and certainly, by tomorrow, they should be at full steam.


MARTIN: Is there any particular area where you think we'll see delays or lags in services from people having to get back up to speed?


DAVIDSON: Well, I think that there's probably going to be some backlog and some paperwork in terms of getting approvals for different things that you might need, you know, government permission to do. Certainly, within the parks - they were closed. And I don't live too far from Rock Creek Park, and I know that while the parks now are officially open, the roads weren't going to open right away because they had to go in there and do some maintenance, just cleaning up things.


You know, there was a bout of heavy rains in Washington during the shutdown - some branches fell, those kinds of things. So some kind of maintenance work in some facilities will probably have to be done before things can be fully operational. I think in many cases, though, you know, the government will kind of gear right up. And remember, much of the government remained open, although in kind of a diminished status. So it's not as if everything came to a total halt.


MARTIN: But it's clear that they were not able to process new requests for government service, like, for example, permits. We've heard a lot about, you know, how permits, new applications for certain kinds of programs, all of those were in (unintelligible). I wanted to focus, though, with you on the effect on the employees. We heard in our earlier conversation with regional editors about some of the effects on the public at large. I wanted to drill down now on the effects on employees.


You and your colleagues at the Post have been asking the public, and there's been an online project asking readers to let them know - to tell us how the shutdown has affected their lives. And you got, in just a couple of days, it's, like, 2000 replies. And apparently you said that the shutdown's distress reaches to every corner of the nation and that almost two-thirds said the shutdown affected them daily or threatened their livelihood. Could you give us just a couple of examples?


DAVIDSON: Well, I think, you know, that was a very good project on the part of my colleagues at washingtonpost.com, to reach out and get a feel for the way the shutdown has been affecting people across the country and particularly for federal employees, particularly those at the lower end of the income spectrum. And there are federal employees who do not make much money, you know, contrary to what some think. They were having a very difficult time just trying to make basic ends meet.


There were stories on that - on that online request for comments about people who could no longer afford babysitters, for example. There were stories of people who could no longer afford school supplies or school uniforms because they were really living check to check. And it's also true that a charity that focuses on federal employees, the Federal Employee Education and Assistance Fund ran out of money for their general fund for employees. But this happened even before the shutdown because there were so many requests from federal employees due to the sequester-related furloughs.


MARTIN: Do you mind if I read a couple of the...


DAVIDSON: Sure.


MARTIN: ...samples of the responses that the Washington Post received? Like, this is from Kentucky. I'm a mortgage broker in Kentucky. I work straight commission. I had three USDA mortgage loans scheduled to close, but now they can't due to government shutdown. I need this money to support my family, not to mention the ripple effect of real estate agents, buyers, sellers, title company, insurance. California - my husband and I are both federal law enforcement officers currently working with no pay. We can't survive if the shutdown goes any longer. We had enough to pay some bills this month, but barely enough for food. If it goes on any longer, we'll have to tap into retirement to pay for necessities. I'm looking for another one. It says here - Alaska - 60 percent of Alaska is owned and managed by the federal government.


The shutdown has affected not only government employees, but those who depend on government services, many of whom live in remote areas and are dependent upon those services. Here's one from Arizona. Federal employee, family of five in a single-income family - second time in six months that I am furloughed. This is day 22 of the government shutdown for me, 11 due to sequester, plus 11 plus due to shutdown - considering leaving government work. Which is my question to you, Joe, do you have any sense of whether - the morale effect of this?


DAVIDSON: Well, I think it definitely does hurt the morale, particularly for folks who are considering federal employment. I think it hurts morale across the board. I don't see how it could not. But I think the impact might be seen most clearly on some young people who are considering, or certainly have considered, working for the federal government. And now they see this on top of the sequester, budget cuts on top of three years of a pay freeze. And I was in touch with a number of them this week for a column - and it's not across the board, it varies from individual to individual - but certainly there are some who are now saying, I'm going to look at the private sector or academia because basically, I can't trust the federal government to kind of take care of my career needs. And I think that could be a dangerous situation in terms of recruiting and retaining talent for the federal government.


MARTIN: Well, for example, we heard from one returning employee who works at NASA, which is certainly a highly technical field. One needs - I don't know this particular person's job - particular job - but most of the people who work there have specific technical skills that are highly sought after. This is what this worker had to say.


UNIDENTIFIED MAN: We're going to be striving to get back on our original schedule, but it's really very disheartening to know how pointless it was to be in the position that we're in today.


MARTIN: Do you have any sense - and I understand that this is difficult to gauge because the tools to measure these things are not always available - but do you have a sense that that's the general perspective? I mean, obviously, you know, we've heard different political points of view, or different points of views depending on political perspective of whether this was a fight worth having or not. Any sense among the federal workforce about that?


DAVIDSON: Well, yeah, I think that there is a feeling among federal workers that they are really kind of like a ping-pong ball being batted back and forth by two paddles, one held by the Democrats and one held by the Republicans. Having said that, though, from my talks with federal employees, I think they clearly tend to blame the Republicans much more than the Democrats for this situation. I think that - but they do feel like they are unnecessarily hurt by a political battle about which they have nothing to do.


They have no control over it. And so many of them are very loyal, probably most of them are very loyal and will continue to work for the federal government, but I think they do resent being on the, you know, kind of being the doormat for members of Congress who can simply use the federal government to advance their political aims, which are not necessarily aims that work to the benefit of the American people and certainly not the federal employees.


MARTIN: Well, one other thing that did emerge is that it appeared that some lawmakers, some elected leaders, didn't really understand exactly what all of them do. I mean, there were a number of incidences where, you know, members of Congress were seen to be berating employees for not really even understanding what their responsibilities were. We only have about a minute left, Joe, but what about their neighbors, what about their friends - do you think that they feel any sense of support from the general public?


DAVIDSON: I think federal employees probably do, although I am, frankly, somewhat worried about that. I think that when you undermine confidence in government, which I think this shutdown has done, I think inevitably, some of that could leak over to federal employees. Having said that, though, I think it's also true that some of the public might now have a better appreciation for federal employees because if they couldn't get some business done that they needed done, they realized that the federal employees are there to serve them and they really do have a strong sense of mission. And so, you know, frankly, it can work both ways. Perhaps there will be some greater appreciation because they now know what federal employees just need - can do for them.


MARTIN: Joe Davidson is a journalist - a columnist at the Washington Post. He writes the Federal Diary column. And he was kind enough to join us from the studios at the Washington Post. Joe Davidson, thanks so much for joining us.


DAVIDSON: Thank you very much.


Copyright © 2013 NPR. All rights reserved. No quotes from the materials contained herein may be used in any media without attribution to NPR. This transcript is provided for personal, noncommercial use only, pursuant to our Terms of Use. Any other use requires NPR's prior permission. Visit our permissions page for further information.


NPR transcripts are created on a rush deadline by a contractor for NPR, and accuracy and availability may vary. This text may not be in its final form and may be updated or revised in the future. Please be aware that the authoritative record of NPR's programming is the audio.


Source: http://www.npr.org/templates/story/story.php?storyId=236240434&ft=1&f=1014
Similar Articles: Jeff Soffer   elizabeth olsen   ricin  

Adidas Is Peddling a $400 Smartwatch To Make You Run Better

Adidas Is Peddling a $400 Smartwatch To Make You Run Better


Adidas is the latest company to hop on the ever-growing smartwatch train. It just showed off its fitness wristwear, which goes on sale November 1 for a whopping $400.

Read more...

Source: http://gizmodo.com/adidas-is-peddling-a-400-smartwatch-to-make-you-run-be-1446454246
Category: taylor swift   Big Brother 15   Anna Kendrick   Derek Medina   Frank Castillo  

Why Scientists Are Trying Viruses To Beat Back Bacteria





Clostridium difficile, a bacterium that causes severe diarrhea, can be difficult to treat with antibiotics.



Stefan Hyman/University of Leicester


Clostridium difficile, a bacterium that causes severe diarrhea, can be difficult to treat with antibiotics.


Stefan Hyman/University of Leicester


Not all viruses are bad for us. Some of them might even help up us fight off bacterial infections someday.


Naturally occurring viruses called bacteriophages attack specific types of bacteria. So researchers at the University of Leicester decided to try and take advantage of phages' bacteria-destroying powers to treat infections with Clostridium difficile, a germ that that can cause severe diarrhea and inflammation of the gastrointestinal tract.


Over the last six years, microbiologist Martha Clokie has isolated hundreds of phages that can kill various strains of C. difficile. Now her lab has teamed up with the pharmaceutical company AmpliPhi to try and turn phages into a product, perhaps a pill, that could be used in humans.


There's no guarantee the approach will work, and so far it hasn't been put to a rigorous test in humans infected with C. difficile. Still, there are some good reasons to check it out.


C. difficile is difficult to treat with antibiotics and is resistant to many of them. Another problem is that the germ often strikes when people take antibiotics to treat other infections. The antibiotics kill good bacteria along with the bad, weakening the gut's defenses against C. diff.


Doctors are using fecal transplants and synthetic poop as possible solutions. But Clokie says that phages could be a useful alternative. "We're simply harnessing the natural enemy of the bacteria," she tells Shots.


Unlike bacteria, Clokie says, phages are very specific about what they attack—right down to the sub-species. In fact, a single phage wouldn't be able to take on all the strains of C. difficle. So Clokie is working to develop a cocktail of viruses that would be able to kill the most common strains.


While the bacteria can evolve and try to outsmart the viruses, the viruses can do the same, Clokie says. They've been involved in this arms race for thousands of years.


As long as they can come up with the right cocktail, there's a very good chance that this phage therapy could work, according to Tim Lu, an associate professor of bioengineering at MIT. "If you know what you want to kill, it's kind of like a silver bullet targeting that bacteria," he tells Shots.



And delivering the phages to a person's gut shouldn't be a challenge, Lu says.


Phages are already approved for use in meat and poultry production. Manufacturers sometimes spray food with phages that target listeria, a common food-borne bacterium.


But using phage therapy in humans is a bit more complicated. "Phages were discovered before antibiotics came around," Lu says. And they've been used in humans, he says. But the problem is, they have yet to be tested in well-controlled clinical trials.


There's also the question of intellectual property. Phages are naturally occurring, and therefore they're difficult to patent, which could discourage pharmaceutical companies.


Ultimately, Lu says, "The science is real." The stuff does work. But, he says, "It's a change in the way we think about treating infections, I think that's the biggest hurdle in a way."


Source: http://www.npr.org/blogs/health/2013/10/18/237080008/why-scientists-are-trying-viruses-to-beat-back-bacteria?ft=1&f=1003
Category: christina milian   Scott Eastwood   Niall Horan   Larry Shippers   Eddie Lacy